PATIENTS > Medication side effects > Skin reactions

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Oral anti-cancer treatments inhibit cancers from expanding, but they could also lead to skin problems. The medications target the epidermal growth factor receptor (EGFR) protein, which signals cancer cells to grow and multiply. The EGFR is also found in normal skin cells and some oral chemotherapy medications impede the cells ability to grow, making it harder to retain moisture. This can lead to dry skin and rashes.

Dry skin

Many people taking oral chemotherapy medications notice their skin becomes dry. Very dry skin is itchy, and scratching can lead to infection.

Symptoms include:

• Dry, peeling skin
• Calluses
• Redness resembling sunburn
• Swelling on palms of hands and feet

Coping strategies to prevent or reduce dryness:

• Forgo a shower and bathe with an oatmeal-based bath product such as Aveeno®
• When showering, keep it lukewarm and short; shower only once daily
• Use an unscented, moisturizing soap

Rash

Most people who develop a rash as a side effect experience a mild skin eruption that resembles acne and may be itchy.

• The scalp, face, chest and upper back are commonly affected
• Skin crusts could become dry and red; round, flat or raised red spots and whitehead pimples with pus may appear
• The rash could appear between seven and 10 days after beginning a course of medication; symptoms sometimes do not appear for up to six weeks after your first dose
• Rashes may come and go with or without medication; a rash should disappear within a month after you finish treatment

Inform your doctor if you notice any rash-related symptoms.

Coping strategies:

• Take a bath and use an oil-based soap or oatmeal bath product such as Aveeno®
• For dry skin or a rash, apply a hypoallergic, unscented cream such as Eucerin® or Aquaphor® while your skin is still damp
• Avoid affixing bandages, dressings or wraps on the skin
• Do not apply acne treatments such as benzoyl peroxide to treat a rash
• Wear loose-fitting cotton clothing
• Wear a hat and sunglasses whenever outdoors
• Avoid direct sunlight and use sunscreen with a SPF of 30 or more

Information provided here does not constitute professional medical advice. Although it is intended to be accurate, neither Walgreen Co., its subsidiaries or affiliates, nor any other party assumes liability for loss or damage due to reliance on this material. If you have a medical question, consult your medical professional.